Physics in Medicine and Biology 2006;51:3419. DOI:10.1088/0031-9155/51/14/010
Contrast-enhanced ultrasound (US) imaging is potentially applicable to the investigation of vascular disorders of the testis. We investigated the ability of two automated computer algorithms to analyse contrast-enhanced pulse inversion US data in a rabbit model of unilateral testicular ischaemia and to correctly determine relative testicular perfusion: nonlinear curve fitting of the US backscatter intensity as a function of time; and spectral analysis of the intensity time trace. We compared (i) five metrics based on the algorithmic data to testicular perfusion ratios obtained with radiolabelled microspheres, a reference standard; (ii) qualitative assessment of the US images by two independent readers blinded to the side of the experimental and control testes to the radiolabelled microsphere perfusion ratios; and (iii) results of the algorithmically-derived metrics to the qualitative assessments of the two readers. For the curve fit method, the algorithmically-derived metrics agreed with the reference standard in 54% to 68% of all cases. For the spectral method, the results agreed in 70% of all cases. The two readers agreed with the reference standard in 40% and 35% of all cases, respectively. These results suggest that automated methods of analysis may provide useful information in the assessment of testicular perfusion.
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Clinic Ultrasound Laboratory (クレメント超音波研究室)
Cleveland Clinic (クリーブランド・クリニック),
Lerner Research Institute
Case Western Reserve University
© 2013
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Clement GT, Nomura H, Adachi H, Kamakura T, Feasibility of non-contact ultrasound for medical imaging, Physics in Medicine and Biology 2013; 58: 6263-6278
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Paltiel HJ, Padua HM, Gargollo PC, Cannon GM Jr, Alomari AI, Yu R, Clement GT. Volumetric ultrasound imaging of tissue perfusion: preliminary results in a rabbit model... Phys Med Biol 2011;56:2183-97.
McDannold N, Clement GT, Black P, Jolesz F, Hynynen K. Focused ultrasound surgery of brain tumors: Initial findings in three patients. Neurosurgery 2010;66:323-32; discussion 332.
Clement GT, Hynynen K. A non-invasive method for focusing ultrasound through the human skull. Phys Med Biol 2002;47(8):1219-36.